Tuesday, October 27, 2009

31 for 21 – Down syndrome Births Drop in UK

Get It Down; 31 for 21

More accurate screening and an increase in the number of younger mothers being screened for Down's syndrome may have forestalled an expected increase in the number of babies born with the condition in the United Kingdom, a study shows.

More accurate screening of moms in the U.K. meant fewer Down's syndrome births, according to new research released this week.

From 1989 to 2008 in the number confirmed prenatal or postnatal diagnoses of Down's syndrome in England and Wales increased by 71 percent -- from 1,075 to 1,843 -- according to Dr. Joan Morris and Dr. Eva Alberman of Barts and the London School of Medicine and Dentistry.

However, the number of babies born with Down's syndrome remained relatively steady despite an increase the age of mothers -- there were 752 in 1989 and 743 in 2008 -- because of terminations following prenatal diagnoses, they reported online in the British Medical Journal. The termination rate remained unchanged.

Dr. James Goldberg of San Francisco Perinatal Associates, past chair of the American College of Obstetricians and Gynecologists' Committee on Genetics, said he didn't know whether there was a similar trend in the United States or in other countries.

He said he believes the situation would be much the same here, although at least one small study has shown an increase in the number of live Down's syndrome births over time in women older than 35.

A spokesperson for ACOG noted that there are no national U.S. data on the number of women who receive prenatal screening for Down's syndrome or reliable data on the number babies born with the disorder.

Morris and Alberman examined data from the U.K.'s National Down Syndrome Cytogenetic Register, which includes about 93 percent of all diagnoses of Down's syndrome in England and Wales.

The database included information on diagnoses in live births and stillbirths, as well as antenatal diagnoses and subsequent terminations, fetal losses, and a small number babies brought to term.

Over the 20-year study period, the large increase in diagnoses occurred even though the overall number of births remained constant.

Starting in about the mid-1990s, the researchers said, screening for Down's syndrome has been improved through new methods and technologies.

Aside from the slightly different ages at which pregnant women were previously recommended for screening in the U.K. and U.S., Goldberg said, screening in the two countries is similar.

Now, in both countries, it is recommended that all pregnant women receive an offer of screening with a discussion of the pros and cons.

Without these improvements in screening, Morris and Alberman said, the number of babies born with Down's syndrome would have increased by an estimated 48 percent -- from 959 to 1,422 -- as a result of women waiting until later in life to have children.

A 40-year-old has about 16 times the risk of having a baby with Down's syndrome as a 25-year-old, they said. During the study period, the proportion of women younger than 37 who underwent screening increased from 3 percent to 43 percent.

The proportion of women 37 and older who underwent screening, on the other hand, remained constant at about 70 percent.

Morris and Alberman said additional studies to determine why more older women don't receive screening for Down's syndrome would be valuable.

"To ascertain whether the decision is an informed one and, if not, to address the lack of information, is important," they said.

During the study, the percentage of pregnant women who received diagnoses of Down's syndrome and went on to have the pregnancy terminated remained steady at about 92 percent.

Goldberg said that in California, data indicate that this proportion is closer to 60 percent.

But he noted that a large database of all Down's syndrome diagnoses does not exist in the U.S., and the figure is likely to vary widely throughout the country.

The ACOG spokesperson said that it's unclear how many terminations result from learning of a Down's syndrome diagnosis, because "[neither] the CDC nor anyone else collects data on the indications for pregnancy terminations."

23 comments:

Rich said...

SEO ServicesSEO Services India SEO Company India SEO Firm India SEO India Mumbai Pune.

SEO Services Consultants said...

Really nice blog, very informative. Thanks dude for wonderful posting. Keep it up in the future as well. SEO Services India

Pooja said...

Nice information, many thanks to the author. It is incomprehensible to me now, but in general, the usefulness and significance is overwhelming. Thanks again and good luck! Web Design Company

Alvin said...

These pictures are so impressive. I am sure my peers will enjoy these too.how to get your ex girlfriend back

SEO Services Consultants said...

I absolutely love your blog and find almost all of your post’s to be precisely what I’m looking for. Does one offer guest writers to write content in your case? I wouldn’t mind creating a post or elaborating on a lot of the subjects you write regarding here. Again, awesome site!
strumpfhosen

SEO Services Consultants said...

Another informative blog… Thank you for sharing it… Best of luck for further endeavor too.

seo services in jaipur

Prol Ectricllc said...

Thanks for the awesome post. Looking forward to staying current with your blog. Keep it up with your good work. I will share your blog with my friends. Thanks
Electrician Galveston

softtrix said...

Thanks for the awesome post. Looking forward to staying current with your blog. Keep it up with your good work. I will share your blog with my friends. Thanks
Home Renovation Guide

Purador said...

Thank you, thats very interesting information. I need to share with my friends.
Argan Oil

softtrix said...

Wow, Fantastic Blog, it’s so helpful to me, and your blog is very good,
I’ve learned a lot from your blog here, Keep on going, my friend, I will keep an eye on it,
Self Improvement Ideas

trainingtampa said...

Your writing is excellent and gives food for thought. I hope that I’ll have more time to read your stories . Regards. I wish you that you frequently publish new texts and invite you to greet me
http://www.trainingtampa.com

SEO Services Consultants said...

Wow, Fantastic Blog, it’s so helpful to me, and your blog is very good,
Fort Lauderdale criminal lawyer

Prem Chand Saini said...

nashville web design There are certainly a lot of details like that to take into consideration.
nashville haircut Hi, I agree with every statement that you have made in the post and I really appreciate your effort in gathering up the information. Thanks for it.
massage nashville Thank you for this great information, you write very well which i like very much. I am really impressed by your post
cca wire Very good post. Hope to see even more great posts in the future.
Home Garden Wood Very good post. Hope to see even more great posts in the future.

Bscc said...

Thank you to tell us so much useful information. So nice sharing. I’m glad to read it.
Credit Counseling Toronto

Vancouver Chiropractor said...

This blog is awesome full of useful information that i was in dire need of.

Vancouver Chiropractor

Fortius Fitness said...

Another informative blog…Thank you for sharing it…Best of luck for further endeavor too.
Jennifer Aniston workout

Fortius Fitness said...

Hello! I just would like to give a huge thumbs up for the great info you have here on this post. I will be coming back to your blog for more soon.
Channing Tatum workout

Fortius Fitness said...

Nice family dear..
Marisa Miller workout

rocky case said...

Stephen Stapinski
Really your blog is very interesting.... it contains great and unique information. I enjoyed to visiting your blog. It's just amazing.... Thanks very much for the share.

oakleyses said...

michael kors pas cher, burberry pas cher, longchamp outlet, prada outlet, louis vuitton, ugg boots, jordan pas cher, nike outlet, ray ban sunglasses, christian louboutin uk, nike air max, oakley sunglasses, nike air max, ugg boots, christian louboutin shoes, chanel handbags, polo ralph lauren, longchamp pas cher, sac longchamp pas cher, louboutin pas cher, oakley sunglasses wholesale, kate spade outlet, cheap oakley sunglasses, nike roshe, polo outlet, christian louboutin outlet, ray ban sunglasses, jordan shoes, tory burch outlet, christian louboutin, replica watches, oakley sunglasses, nike free run, longchamp outlet, replica watches, louis vuitton, louis vuitton outlet, uggs on sale, ray ban sunglasses, polo ralph lauren outlet online, gucci handbags, tiffany jewelry, louis vuitton outlet, louis vuitton outlet, oakley sunglasses, air max, nike free, tiffany and co, longchamp outlet

oakleyses said...

timberland pas cher, nike blazer pas cher, true religion outlet, hollister uk, nike air force, mulberry uk, hogan outlet, true religion jeans, nike free uk, oakley pas cher, coach outlet store online, michael kors outlet, north face, michael kors outlet online, nike air max, true religion outlet, michael kors, vans pas cher, hollister pas cher, sac hermes, michael kors outlet online, polo lacoste, burberry handbags, uggs outlet, burberry outlet, ray ban pas cher, michael kors outlet online, kate spade, north face uk, michael kors outlet, new balance, michael kors outlet, ray ban uk, sac vanessa bruno, guess pas cher, nike air max uk, nike roshe run uk, ralph lauren uk, michael kors, michael kors outlet online, abercrombie and fitch uk, converse pas cher, true religion outlet, nike tn, replica handbags, coach purses, uggs outlet, nike air max uk, coach outlet

oakleyses said...

vans outlet, lululemon, valentino shoes, nike air max, wedding dresses, nike roshe run, p90x workout, reebok outlet, chi flat iron, jimmy choo outlet, herve leger, baseball bats, timberland boots, soccer shoes, instyler, mcm handbags, north face outlet, ray ban, converse outlet, iphone cases, babyliss, hermes belt, new balance shoes, mont blanc pens, lancel, louboutin, soccer jerseys, ghd hair, mac cosmetics, celine handbags, hollister, asics running shoes, ferragamo shoes, hollister, north face outlet, abercrombie and fitch, oakley, longchamp uk, vans, beats by dre, gucci, bottega veneta, ralph lauren, nike huaraches, nike air max, hollister clothing, insanity workout, nike trainers uk, nfl jerseys, converse

oakleyses said...

moncler, ugg,uggs,uggs canada, supra shoes, louis vuitton, pandora charms, louis vuitton, ugg pas cher, juicy couture outlet, marc jacobs, ugg,ugg australia,ugg italia, canada goose, canada goose outlet, moncler outlet, pandora jewelry, ugg, replica watches, wedding dresses, louis vuitton, toms shoes, karen millen uk, links of london, louis vuitton, montre pas cher, moncler, moncler uk, canada goose jackets, canada goose, ugg uk, coach outlet, canada goose uk, canada goose, hollister, doudoune moncler, louis vuitton, swarovski, moncler, swarovski crystal, moncler outlet, juicy couture outlet, moncler, thomas sabo, canada goose outlet, pandora uk, canada goose outlet, pandora jewelry